This course is addressed towards students, researchers and engineers carrying out experiments in their fields of study and work. In depth knowledge of probability and statistics, though helpful, is not a pre-requisite to understand the contents of this course. The first part of the course deals with random variables, typical probability distributions, random sampling, confidence intervals on population parameters and hypothesis testing. These form the basic background of statistical analyses.
In the second part of this course, design of experiments and regression analysis are introduced. The factorial design of experiments involving two or more factors is discussed in detail. Properties of orthogonal designs and other popular design strategies such as the Central Composite Design and Box Behnken design are also discussed. The characteristic features of experimental design strategies are defined and compared.
Linear regression model building concepts are explained using which empirical models may be fitted to experimental data. The methods to assess the quality of the models fitted are discussed.
Identification of optimum performance of the process through experimental investigations is demonstrated through the response surface methodology approach.
After understanding this course material, the experimentalist will develop the confidence to identify an appropriate design strategy suited for his work. He will also be able to interpret the results of the experiments in a scientific manner and communicate them unambiguously.

Random Variables

Introduction to discrete and continuous random variables, quantify spread and central tendencies of discrete and continuous random variables

Important Statistical Distributions

Properties and applications of Normal, log-normal and t-distributions, Chi-Square and F distributions

Point and interval estimates of population parameters

Point Estimation of the population mean, distribution of the sample means, central Limit theorem, confidence Intervals on the population mean, optimal sample size to obtain precision and confidence in interval estimates of mean, maximum likelihood parameter estimation

Hypothesis Testing

Formulation of null and alternate hypotheses, errors in hypothesis Tests, power of hypothesis tests, hypothesis tests on population means, variances and ratios of variances

Analyze single factor experiments

Introduction to Analysis of Variance (ANOVA), blocking and randomization

Factorial Design of Experiments

Need for planned experimentation, factorial design experiments involving two factors, effect of interactions, ANOVA in factorial design, general factorial design, partial factorial designs

Linear Regression Analysis

Matrix approach to linear regression, Variance-Covariance matrix, ANOVA in regression analysis, quantifying regression fits of experimental data, Extra sum of squares approach, confidence intervals on regression coefficients, lack of fit analysis

Comparison of different experimental design strategies

Properties of orthogonal designs, implications of different factorial design models, importance of center runs, scaled prediction variance, central composite design, Box-Behnken design, moments of experimental designs, rotatable of experimental designs, face centered cuboidal designs, comparison of experimental designs

Response Surface Methodology

Method of steepest ascent, first and second order models, identification of optimal process conditions

Detailed Course Plan – Part 1

Lecture No.

Topic

1

Introduction and overview

2

Random Variables

3

Discrete Probability Distributions

4

Example Problems

5

Continuous Probability Distributions

6

Normal and Log Normal Probability Distributions

7

t-distribution

8

Chi-Square Distribution

9

F-distribution

10

Example Problems

11

Example Problems

12

Distribution of the random sample mean

13

Central Limit Theorem and its applications

14

Confidence Intervals

15

Maximum Likelihood Parameter Estimation

16

Example Problems

17

Formulation and Testing of Hypotheses

18

Errors in Hypothesis Testing

19

Hypothesis tests on population means, variances and ratio of variances

20

Example Problems

Detailed Course Plan – Part 2

Lecture No.

Topic

21

Design and Analysis of Single Factor Experiments

22

Randomized Block Design

23

Example Problems

24

Factorial Design with Two Factors

25

Factorial Design with Multiple Factors

26

Fractional Factorial Design

27

Example Problems

28

Matrix Approach to Linear Regression Analysis

29

Variance-Covariance Matrix

30

ANOVA in regression Analysis and Confidence Intervals

31

Extra Sum of Squares

32

Lack of Fit Analysis

33

Example Problems

34

Properties of Orthogonal Designs

35

Importance of Center Runs

36

Central Composite Design

37

Box Behnken Design and Face Centered Designs

38

Response Surface Methodology : Method of Steepest Ascent

39

Identification of optimal process conditions

40

Example Problems

Basic knowledge on Calculus, linear algebra and elementary knowledge on probability

Montgomery, D. C., G.C. Runger, Applied Statistics and Probability for Engineers. 5th ed.New Delhi: Wiley-India, 2011.

Montgomery, D. C., Design and Analysis of Experiments. 8th ed.New Delhi: Wiley-India, 2011.

Myers, R. H., D. C. Montgomery and C. M. Anderson-Cook, Response Surface Methodology. 3rd ed. New Jersey: Wiley, 2009.

Ogunnaike, B. A., Random Phenomena. Florida: CRC Press, 2010.

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