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Course Co-ordinated by IIT Kharagpur
Prof. Samik Nanda
IIT Kharagpur


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Organic synthesis of small molecules is the most challenging and intriguing area of research in the chemical science related disciplines. In the early 20th century, the field of synthetic organic chemistry, while established in many respects, was to continue a sharp path of progress and advancement for over a century to reach the level of power and sophistication that it possesses today. This is a unique tool for accessing new chemical entities with great biological potential, which seems to be impossible to access from natural sources due to its scarce availability. In this coursework I will try to address various aspects of organic synthesis through a problem/puzzle solving approaches so that students can learn in an interactive manner and excel in competitive exams.




Introductory remarks: Why to study organic synthesis? Historical perspectives of organic synthesis.
Establishing a visual dialogue with the target molecules (imagination, creativity and execution).


†Retrosynthetic disconnections: The basis for retrosynthetic analysis and terminologies,
Transform based strategies, Substrate/precursor based strategies.


Retrosynthetic disconnections: Functional group based strategy
(concept of redundant functionality) and mechanism based strategy (including biomimetic pathways)


Retrosynthetic disconnections: Consideration of symmetry elements in synthetic planning;
Local symmetry and pseudo symmetry. Synthesis of symmetrical molecules and concoctive species.


Retrosynthetic disconnections: Stereochemical strategies Strategies to create new chiral center/s in a organic molecule
(Resolution, Desymmetrization, Substrate directed approach, Chiron approach, Absolute asymmetric synthesis)


Retrosynthetic disconnections: Enantiodivergent and enantioconvergent approaches and case studies (meso trick and C2-trick).


Synthetic equivalents: Concepts of synthetic equivalents (formyl/acyl anion, enolate, homoenolate,
Conjunctive species, Linchpin strategy and other related species) and its application in total synthesis.


Fragmentation reactions (Overbred intermediates) and molecular rearrangements and its application in organic synthesis


Stereochemistry and conformational analysis: Concepts and application of A1,2/A1,3 strain. Baldwinís cyclization rule.


Protecting groups: Selective protection and deprotection of various functional groups and its application in total synthesis


Few important name reactions and their applications in organic synthesis
(Several name reactions based on Substitution/displacement strategy, Reductive strategy,
Oxidative strategy, Coupling reactions, Cyclization reactions


Total synthesis of few natural products: Longifolene (Corey/ Oppolzer);
Isocomene (Pirrung); Hirsutene and Δ9(12) Capnellene (Curran), Taxol (Nicolaou); Epothiolone A & B (Nicolaou).

  • Basic Organic Chemistry
  • Stereochemistry


1. The Logic of Chemical Synthesis by E. J. Corey and X.M. Cheng 
2. Organic synthesis: Strategy and Control; by Paul Wyatt and Stuart warren 
3. Modern Organic Synthesis: G. S. Zweifel, M. H. Nantz and P. Somfai 
4. (for a list of name reactions and other details) 
5. Strategic Applications of named Reactions in Organic Synthesis: L. Kurti and B. Czako 



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