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Course Co-ordinated by IIT Kharagpur
Coordinators
 
Prof. A. Basak
IIT Kharagpur

 

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Stereochemistry of molecules dictates isomerism, chemical and biochemical reactivity. Reactivity. These days, chiral drugs have become an integral part of pharmaceutical industry. A basic concept on 3D structures and conformations of molecules and asymmetric synthesis and other stereochemical principles and attributes are essential. This course will lay the foundation on to which further advanced topics can be built up.

Module Name
Lessons/Topics
Module 1 Constitution and Configuration; Chemistry in 3D space Chirality and its origin, symmetry criterion
Module 2 Stereogenicity and topicity; Enantiomers, Diastereomers, Epimers, Anomers, Atropisomers
Module 3 Nomenclature: Absolute (R/S and D,L) and relative configurations (Threo/erythro , syn/anti and like/unlike)
Module 4 Prochirality, pro-R and pro-S designations; related problems
Module 5 Conformations of acyclic systems: X-CH2-CH2-X and of cyclic systems: cyclopropane, cyclobutane, cyclopentane
Module 6 Conformations of cyclohexane (including mono and disubstituted), cis and trans-decalins
Module 7 Stereoelectronic and steric principles in reactions: Substitution, elimination and addition; selectivity and specificity
Module 8 Stereoelectronic and steric principles in reactions: Substitution, elimination and addition; selectivity and specificity (contd); Importance of stereochemistry in real life: some examples

B.Sc,
Stereochemistry by Eliel, Stereochemistry by Nasipuri and Organic Chemistry by Clayden et. al.

Nil

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