Chapter 6

Nucleophilic substitution Reactions

In this module, details of different types of nucleophilic substitution reactions are described. These reactions are an useful class of reactions for carbon-carbon and carbon-heteroatom bond formation reactions. The approach is also widely used for synthetic transformations (e.g., leaving groups such as tosylates). Depending on the nature of the nucleophiles and reaction conditions, different mechanisms are possible. These reactions typically occur on a saturated carbon atom, attached to a leaving group. You will find terminologies such as intermediates, transition states etc., in this module.

I. Nucleophilic substitution reactions bimolecular (SN2)

  • The notation SN2 represents Substitution Nucleophilic Bimolecular.
  • This mechanism is a concerted process in which the bond forming and bond breaking occur simultaneously.
  • Energy required to break the bond is compensated by bond formation.