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Course Co-ordinated by IISc Bangalore
Coordinators
 
Prof. Bikramjit Basu
IISc Bangalore

 

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Biomaterials, recognized as a new class of materials in the Materials Science community, are being developed in last few decades for human health care. The design and development of biomaterials requires the integration of the concepts and expertise from two widely different disciplines, i.e. Materials Science & Engineering and Biological Science. The importance of the field of biomaterials is increasingly being noticed in the Materials community with the compulsory course on this subject is being taught at undergraduate and graduate level in most of the top universities around the world. In India, a compulsory course on biomaterials is being kept in the new course curriculum of undergraduate students in Department of Materials Science and Engineering at IIT Kanpur, while this instructor has taught a more elaborate course on biomaterials for the graduate students at IIT Kanpur and at IISc, Bangalore, over last one decade. This NPTEL course on “Biomaterials for Bone Tissue Engineering applications” will consist of several lectures on the basics of the cell biology and biomaterials science, followed by some case studies, illustrating various aspects of biomaterials development for orthopedic applications. The layout of this lecture series in terms of the succession of various concepts will primarily facilitate easier understanding for students and this important area of societal relevance in terms of human healthcare.

 

Week

Topics

1.

Introduction to Biomaterials and Biocompatibility

M1-Introduction, M2-Biomaterial, M3-Biocompatibility, M4- Host response

2.

 Defining tissue engineering scaffolds and implants

M5-Tissue Eng, M6-Scaffold, M14-Bone structure, M15-Bone properties, M16-Implant-I, M17-Implant-II

3.

Structure and Properties of Proteins and Cells

M7-Proteins, M8-Cell structure, M13-Bacteria structure, M27-Antibacterial assay

4.

Stem cells and Cell fate processes

M11-Cell fate processes, M12-Cell division, M23-Cell differentiation, M24-Stem cells

5.

Cell-material Interaction (in vitro and in vivo) and Clinical trials

M18-Osseointegration, M19-in vivo testing, M9-Cell-material interaction, M10-Cell-signalling, M21-in vitro testing, M22-Cytotoxicity assays, M25-Clinical trials I, M26-Clinical trials II

6.

Manufacturing of Biomaterials (metals, ceramics and polymers)

M28-Metal manufacturing, M29-Ceramics manufacturing, M30- Polymers manufacturing, M31-Additive manufacturing

7.

HA-based composites

M32-HA-Ti-Toughness, Cell functionality, M33-HA-CaTiO3 development, M34-HA-BaTiO3 Functional Prop, M35-HA-Ag antimicrob & cell viability, M36-HA-ZnO, Cell fate & antimicrobial

8.

Glass ceramics for orthopedic and dental applications, acetabular socket and femoral head, prototype development

M37-Dental ceramics: processing, M38-Sr-based glass Ceramics, M39-Acetabular socket (Compression mold), M40-ZTA femoral ball head fabrication

  1. B. Basu, D. Katti and Ashok Kumar; Advanced Biomaterials: Fundamentals, Processing and Applications; John Wiley & Sons, Inc., USA (ISBN: 978-0-470-19340-2), September, 2009.
  2. Biomaterials Science: An introduction to Materials in Medicine, Edited by Ratner, Hoffman, Schoet and Lemons, Second Edition: Elsevier Academic Press, 2004.
  3. Biomaterials Science and Biocompatability, Fredrick H. Silver and David L. Christiansen, Piscataway, Springer, New Jersey.
  4. Biological Performance of Materials: Fundamentals of Biocompatibility, Janathan Black, Marcel Dekker, Inc., New York and Basel, 1981.


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