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Course Co-ordinated by IIT Kanpur
Coordinators
 
Dr. Birkamjit Basu
IIT Kanpur

 
Dr. Kantesh Balani
IIT Kanpur

 

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Introduction to basic concepts of Materials Science; Salient properties of important material classes; Property requirement of biomaterials; Concept of biocompatibility; Structure and properties of biological cells & tissues; cell-material interactions and foreign body response; Assessment of biocompatibility of biomaterials, in vitro biochemical assays (cellular adhesion, cellular viability using MTT, osteogenic differentiation using ALP assay; Biomnuneralisation using Osteocalcin assay);

In vivo testing and histocompatibility assessment; genotoxicity assessment (Physical damage to DNA by biomaterial eluates); important biometallic alloys: Ti-based, stainless steels, Co-Cr-Mo alloys; Bioinert, Bioactive and bioresorbable ceramics; Processing and properties of different bioceramic materials with emphasize on hydroxyapatite; synthesis of biocompatible coatings on structural implant materials; plasma spraying of carbon nanotube reinforced hydroxyapatite on Ti-6Al-4V substrate; Microstructure and properties of glass-ceramics; biodegradable polymers; Design concept of developing new materials for bio-implant applications.

 

Sl. No

Topic

Lecture Numbers

1.

Introduction to basic concepts of Materials Science; Salient properties of important material classes

1-3

2.

Property requirement of biomaterials; Concept of biocompatibility

4-5

3.

Structure and properties of biological cells & tissues

6-7

4.

Cell-material interactions and foreign body response

8-10

5.

Assessment of biocompatibility of biomaterials

11

6.

In vitro biochemical assays (cellular adhesion, cellular viability using MTT, osteogenic differentiation using ALP assay; Biomnuneralisation using Osteocalcin assay)

12-15

7.

In vivo testing and histocompatibility assessment

16-17

8.

Genotoxicity assessment (Physical damage to DNA by biomaterial eluates)

18

9.

Important biometallic alloys: Ti-based, stainless steels, Co-Cr-Mo alloys

19-21

10.

Bioinert, Bioactive and bioresorbable ceramics

22-24

11.

Processing and properties of different bioceramic materials with emphasize on hydroxyapatite

25-27

12.

Synthesis of biocompatible coatings on structural implant materials

28-29

13.

Plasma spraying of carbon nanotube reinforced hydroxyapatite on Ti-6Al-4V substrate; in-vitro cytocompatibility

30-32

14.

Microstructure and properties of glass-ceramics

33-34

15.

Biodegradable polymers

35-37

16.

Design concept of developing new materials for bio-implant applications

38-40

  1. Biomaterials Science: An introduction to Materials in Medicine, Edited by Ratner, Hoffman, Schoet and Lemons, Second Edition: Elsevier Academic Press, 2004.

  2. Comprehensive structural interity, Vol.9: Bioengineering Editors: Mithe, Ritchie and Karihalo, Elsevier Academic Press, 2003.


  1. Biomaterials Science and Biocompatability, Fredrick H. Silver and David L. Christiansen, Piscataway, Springer, New Jersey.

  2. Biological Performance of Materials: Fundamentals of Biocompatibility, Janathan Black, Marcel Dekker, Inc., New York and Basel, 1981.

  3. Basic Cell Culture: A Practical Approach, Edited by J.M. Davis, IRL Press, Oxford University Pres, New York, 1994.



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