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This course covers topics on Introduction to BioMEMS and microfluidics,Important materials for fabrication of BioMEMS platforms,Design of ISE. Finding selectivity coefficient for a mixed ion system.,Introduction to Cell biology, Basic structure of DNA,Protein charging at different pH range, Amino acids, protein polymerization, Transcription , Translation,Micromixers: Design and  mixing principales,Etching techniques, evaporation and sputtering & Photolithography techniques.

 

Week. No

Topics

1.

  • Introduction to BioMEMS and microfluidics
  • Introduction to Bio nano technology, Biosensors, fluidics.
  • Introduction to device fabrication (Silicon and Polymers)
  • Introduction to device fabrication (Silicon and Polymers) continued..
  • Sensors, Transduction and Performance factors.
  • Sensors, Transduction and Performance factors continued

2.

  • Important materials for fabrication of BioMEMS platforms
  • Introduction to silicon device fabrication
  • Some Fabrication Methods for soft materials
  • Transduction Methods. About cell potential and SHEs
  • Cell reaction, Nernst equation, Construction of Ion selective  electrodes
  • Measurement and calibration of electrodes, ion-solvent interaction

3.

  • Design of ISE. Finding selectivity coefficient for a mixed ion system.
  • ISE continued.. Gas sensing electrodes
  • Applications for biosensors in Diagnostics , Zeta potential and the model  for electrode.
  • Flow between two fixed plates. Comparison between plug like flow of electro-osmosis Vs parabolic flow.
  • Electro-kinetic flow in silicon channels. Design of electro-kinetic network.
  • Design of electro-kinetic network. Flow rate calculations. Selection of good materials, Streaming potential.

4.

  • Introduction to Cell biology, Basic structure of DNA
  • DNA hybridization, , DNA polymerization, PCR
  • Thermal cycle , Real Time PCR.PCR design
  • Electrophoresis, Gel and Capillary electrophoresis, Agarose
  • DNA microarrays (concepts,  and utility). Affymetrix and Nanogen approaches in realization of micro-arrays.
  • DNA sequencing (Sanger’s reaction). DNA nano-pores. DNA detection using Mechanical Cantilevers. Basics of Protein structure.

5.

  • Protein charging at different pH range, Amino acids, protein polymerization, Transcription , Translation
  • Antibody, Microencapsulation, Cyclic voltametry
  • Microfluidics, Similarity of Streamlines, Pathlines, Sreaklines and Timelines for a steady flow
  • Stress tensor. Viscosity. Newtonian, non-Newtonian fluids, Pseudoplastic, Dilatant, Bingham Plastic materials, Thixotropic fluids.
  • Flow over infinite plates, laminar and turbulent flow, Compressible and Incompressible flows
  • Flow over an infinite plate. Types of flows. Types of Fluids. Kinematics of fluids

6.

  • Micromixers: Design and  mixing principales
  • Microvalves : Designing of pneumatic and thermo pneumatic valves.
  • Hydrogel  based valves. Electrochemical valves.
  • Micropumps
  • Microelectronic-fabrication processes: Review of basic fabrication processes for silicon
  • Introduction to microelectronic fabrication, Optical lithography, photo-resists.

7.

  • Etching techniques, evaporation and sputtering. 
  • Vacuum science and plasmas, Theory  of plasma
  • Review of basic fabrication processes for polymers
  • Polymer materials for microsystems, Polymeric micromachining technology.
  • Bulk and surface micro machining, Replication technologies, laser machining,
  • micro-stereo lithography, micro-molding, Assembly and packaging.

8.

  • Photolithography techniques
  • Functionality of Polymer PDMS   used in micro technology
  • Additive techniques, Thermal oxidation
  • Single crystalline silicon, Subtractive technique.
  • Overview of Lab-on-chip technology/ biomedical and chemical sensors, specific cases: Integrated gene analysis systems
  • Chip technology (Integrated analysis of pathogenic bacteria), Electrochemical and optical (labeled and unlabeled).

Atleast B. Tech or final year undergraduate if the candidate is from IIT or NIT



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