Fundamental knowledge of bioprocess calculations, basic principles of bioprocess operations, medium design & optimization and bioreactor handling.
Basic concepts. Fundamentals of material and energy balance for processes with/without chemical reaction. Simultaneous mass and energy balance in flow and without flow conditions.
Nutritional requirements for growth and product formation. Medium design and optimization with statistical analysis (ANOVA), Placket-Burman and Central Composite Design technique. Pre-treatment of industrial raw materials.
Types of sterilization, thermal death kinetics of microorganism. Heat sterilization of liquid medium in batch and continuous mode. Air sterilization.
Different types of bioreactors, configuration of Bioreactors and their main components. Modes of bioreactor operation. Important bioreactor accessories.
Inoculum development. Various types of Fermentation, submerged fermentation, aerobic and anaerobic fermentation. Overview of biosynthetic mechanisms. Metabolic stoichiometry. Case studies.
M.L.Shuler and F.Kargi, "Bioprocess Engineering--basic Concepts", 2nd Edn. Prentice-hall Of India Pvt Ltd (2008).
P.M.Doran, "Bioprocess Engineering Calculations", Elsevier India Pvt Ltd (2008).
C. Ratledge & B. Kristiansen, "Basic Biotechnology" 3rd Edn. Cambridge University Press (2008).
Peter F. Stanbury, Stephen J. Hall & A. Whitaker, "Principles of Fermentation Technology", ¬†Elsevier India Pvt Ltd.(2007).
D.M. Himmelblau, "Basic Principles and Calculations in Chemical Engineering", 6th Edn, Pearson Education (2006).
L.E.Casida, Jr, "Industrial Microbiology", New Age International Pvt Ltd (1968).
Relevant web sites.
Biochemical Engineering Journal.
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