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Course Co-ordinated by IIT Madras
Coordinators
 
Prof. Mukesh Doble
IIT Madras

 

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A product that is manufactured in a bioreactor or a fermentor, is recovered and purified in several subsequent unit operations. The economy of a manufacturing process is determined by the cost effectiveness of these downstream operations. This course discusses these operations and the basic underlying principles with worked out problems. This course will be useful for UG/PG students in biotechnology/chemical engineering as well as practicing bioprocess and chemical engineers. 

 

Module 1

Introduction


Mass balance, Heat Balance, flow sheet


Costing


Cell Breakage

Module 2

Solid Liquid Separation


Pre-treatment and Filters/centrifuge


Liquid-Liquid Extraction


Liquid-Liquid extraction (continued)

Module 3

Adsorption


Reversed micellar and aqueous two phase extraction


Membranes


Membranes (continued)

Module 4

Precipitation and crystallization


Product stabilization, drying, Lyophilisation


Electrophoresis / SDS PAGE


Chromatography

Module 5

Chromatography (continued)


Chromatography (continued)


Chromatography (continued)


Future trends, Other downstream operations/Summary of the course

Basics of physics/chemistry/Maths, Mass and heat balance, and thermodynamics


Revise and read books pertaining to down stream processing. Listen to my NPTEL––40hrs lectures "Downstream Processing" course.



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